Trump Had Hidden $19.8 Million Loan From North Korea-Linked Company As President: Report

HuffPost

Trump Had Hidden $19.8 Million Loan From North Korea-Linked Company As President: Report

Mary Papenfuss – December 5, 2022

Donald Trump failed to disclose a $19.8 million loan from a company with ties to North Korea while he was president, Forbes reported Sunday, citing documents uncovered by the New York attorney general’s office.

Trump owed the money to L/P Daewoo while he was campaigning in 2016 and into his presidency, according to records. He didn’t list the debt in financial disclosure filings, as candidates and presidents are expected to do, Forbes reported.

The loan was paid off just over five months into his presidency. Forbes said the documents don’t specify who satisfied it.

Daewoo is a South Korean conglomerate that partnered with Trump on a development project near the United Nations headquarters in New York City and on several other projects over the years. The company has ties to North Korea, Forbes reported, and was the only South Korean company allowed to operate a business in North Korea in the mid-1990s.

Trump may have skirted disclosure laws and not committed an outright violation because the loan was on the books of his company, the Trump Organization, and not identified as a personal loan, Forbes noted.

The debt would have sparked conflict of interest concerns over an American president’s indebtedness to a foreign operation vulnerable to influence by North Korea’s rogue government. Trump often gushed about his close relationship with North Korean leader Kim Jong Un.

Such loans are largely reported on an honor system because the U.S. Office of Government Ethics has neither the resources nor the power to delve into a president’s assets.

“If someone does not disclose a loan, OGE has no way to know,” said Walter Shaub, who ran that agency when Trump took office.

Don Fox, who once also headed the office, told Forbes:“The system is kind of predicated upon people actually following a law because they want to follow the law.”

Check out the Forbes article here.

Related…

Anavex’s (AVXL) Lead Alzheimer’s Drug Meets Study Goal

Zacks

Anavex’s (AVXL) Lead Alzheimer’s Drug Meets Study Goal

Zacks Equity Research – December 5, 2022

Shares of Anavex Life Sciences AVXL were up 35.9% on Dec 2 after management reported positive topline data from a phase IIb/III study which evaluated its lead pipeline candidate ANAVEX 2-73 (blarcamesine) in Alzheimer’s disease (AD) indication.

The phase IIb/III study, or the ANANVEX 2-73-AD-004 study, evaluated ANAVEX 2-73 for the treatment of mild cognitive impairment (MCI) due to AD and mild AD (collectively known as early AD)

The ANAVEX 2-73-AD-004 study achieved its primary and key secondary endpoints. Treatment with ANAVEX 2-73 showed robust, statistically significant and clinically meaningful absolute improvement in cognitive functions as measured by ADAS-Cog and ADCS-ADL that were the study’s primary endpoints over a 48-week treatment period in the analysis of the intent-to-treat (ITT) population.

Data from the study showed that study participants who received ANAVEX 2-73 were 84% more likely to have improved cognition than those who were administered placebo. Patients treated with ANAVEX 2-73 were 167% more likely to improve function than those participants who were receiving a placebo. The treatment also showed a statistically significant reduction in cognitive decline at the end of treatment by 45%, when compared with placebo.

The study also met its secondary endpoint of reduction in clinical decline of cognition and function, as measured by CDR-SB score. Data from the study showed a 27% reduction in the ITT population when compared to placebo-administered participants.

The ANAVEX 2-73-AD-004 study randomized AD participants into three equal groups – one group which received a mid-dose of ANAVEX 2-73, a second group, which received a high-dose of the drug and a third group which received placebo.

Anavex continues to conduct a further analysis the above data and intends to submit the same for publication in a peer-reviewed medical journal. Management is also conducting an open-label extension study ATTENTION-AD to follow study participants over a 96-week treatment period.

Shares of Anavex have declined 30.5% this year compared with the industry’s 16.7% fall.

Zacks Investment Research
Zacks Investment Research


Image Source: Zacks Investment Research

The results of the ANAVEX 2-73-AD-004 study are also consistent with the phase IIa ANAVEX 2-73 study previously conducted by the company. Data from the phase IIa study had demonstrated a therapeutic effect on cognition and function.

Per management, AD is one of the leading causes of deaths in older adults aged above 65 years and is also the most common cause of dementia in this age group. Treatment with ANAVEX 2-73 demonstrated a reversal of cognitive decline.

Apart from AD, Anavex has also successfully completed clinical studies evaluating ANAVEX 2-73 in other indications. These include a phase II proof-of-concept study on Parkinson’s disease dementia and a phase III study in adult patients with Rett syndrome.

Anaex’s target market is highly competitive as several other pharma companies like Biogen BIIB and Eli Lilly LLY are also developing their candidates targeting the AD indication. The Alzheimer’s candidates of these companies — anti-amyloid beta antibodies — are in late-stage development or review and are expected to be launched in a few months.

Last week, Biogen along with partner Eisai presented detailed data from the phase III confirmatory study CLARITY AD, which evaluated its AD candidate lecanemab (BAN2401) to treat early AD. The data showed that Biogen’s candidate did reduce markers of amyloid in early Alzheimer’s disease and led to moderately less decline in measures of cognition and function than placebo at 18 months. However, treatment with lecanemab was associated with adverse events.

Biogen/Eisai have already filed their biologics license application (BLA) seeking accelerated approval for lecanemab with the FDA, supported by data from a phase II study (Study 201). A final BLA decision is expected by Jan 6, 2023.

Eli Lilly has developed donanemab, an investigational antibody therapy, for AD. Eli Lilly initiated a rolling submission with the FDA last year, seeking approval for donanemab under the accelerated pathway based on data from the phase II TRAILBLAZER-ALZ study. A final decision on the BLA is expected in early 2023. Eli Lilly also expects a data readout from the pivotal phase III TRAILBLAZER-ALZ 2 by mid-2023. If positive, the data will form the basis of its application for traditional regulatory approval for donanemab.

Last month, Roche RHHBY announced the failure of the GRADUATE I and II studies, evaluating its monoclonal antibody gantenerumab in early AD. The studies failed to meet their primary endpoint of slowing clinical decline. Patients treated with Roche’s gantenerumab showed a slowdown of clinical decline in GRADUATE I and GRADUATE II, which was not statistically significant. Per Roche, the level of beta-amyloid removal was lower than expected.

Anavex Life Sciences Corp. Price

Anavex Life Sciences Corp. Price
Anavex Life Sciences Corp. Price

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Corporate landlords are gobbling up mobile home parks and rapidly driving up rents

MoneyWise

Corporate landlords are gobbling up mobile home parks and rapidly driving up rents — here’s why the space is so attractive to them

Vishesh Raisinghani – December 5, 2022

Corporate landlords are gobbling up mobile home parks and rapidly driving up rents — here’s why the space is so attractive to them
Corporate landlords are gobbling up mobile home parks and rapidly driving up rents — here’s why the space is so attractive to them

The hunt for yield has pushed private equity firms and professional investors into new segments of the real estate market.

In recent years, sophisticated investors have snapped up multi-family units and single-family homes. Now, corporate landlords are targeting the most cost-effective segment of the real estate market: mobile home parks

The most affordable U.S. housing option

Manufactured homes or mobile homes are considered the most affordable non-subsidized housing option in America. That’s because the owners own only the prefabricated unit and not the land under the home. The land is usually leased from the landlord of a trailer park.

The average monthly rent for a mobile home in 2021 was $593. That’s significantly lower than the average one-bedroom condo rental rate of $1,450. The mobile park rental also often includes utilities and insurance.

Rents typically rise 4% to 6% annually and renters have the flexibility to move their housing unit to another park. These factors make the manufactured home highly attractive to low-income households.

As of 2020, nearly 22 million Americans lived in mobile homes. That’s 6.7% of the total population or about one in 15 people across the country. However, the economic inefficiencies that make these manufactured homes affordable also make them attractive to professional investors.

Investing in mobile home parks

Factors such as below-market rents and disrepair make mobile home parks attractive for investors seeking to add value. The typical mobile home park lot costs $10,000, which means 80 lots would be worth $800,000 on average.

Put simply, the entry price for these parks is much lower than multi-family apartments and condo buildings across the country.

Professional investors can also raise rents significantly to improve the valuation of the property. Attracting tenants with higher incomes or improving the park’s amenities and infrastructure are other value-add strategies that make this asset class appealing.

The fact that moving a typical mobile home costs between $3,000 to $10,000 also means that most tenants are unable to afford the move. This gives landlords immense pricing power.

Meanwhile, the yield is much higher. The capitalization rate (the ratio of net operating income to market price) could be as high as 9%, according to real estate partners Dave Reynolds and Frank Rolfe, who together are the fifth-largest owner of mobile home parks in the U.S.

The largest mobile park landlord is real estate veteran Sam Zell. Zell’s Equity LifeStyle Properties (ELS) owns 165,000 units across the country and the asset is a key element of his $5.4 billion fortune.

In recent years, larger investors such as Singapore’s sovereign wealth fund GIC and private equity firms such as The Carlyle Group, Brookfield, Blackstone, and Apollo have also added exposure to this asset class.

Even Warren Buffett is involved. His firm’s subsidiary, Clayton Homes, is the largest manufacturer of mobile homes in the U.S., and also operates two of the biggest mobile home lenders, 21st Mortgage Corp. and Vanderbilt Mortgage.

You can invest too

Retail investors looking for exposure to mobile home parks have plenty of options. Acquiring a park is, perhaps, the most straightforward way to access this asset class. However, publicly-listed stocks and real estate investment trusts offer exposure too.

Sam Zell’s Equity LifeStyle Properties is listed on the New York Stock Exchange under the ticker ELS. Sun Communities Inc. (SUI) owns 146,000 units across the U.S. and some in Canada, while Legacy Housing Corp. (LEGH) builds, sells, and finances manufactured homes.

Retail and institutional investors could see more upside from this segment as the economic inefficiencies are ironed out.

How I’m Staying in Shape by Turning My Daily Stroll Into Hard Exercise

Barron’s

How I’m Staying in Shape by Turning My Daily Stroll Into Hard Exercise

Neal Templin – Dec. 3, 2022

Sure, walking is good for you. But a few changes to your routine could turn it into a heart-thumping exercise.Dreamstime


If I read one more time that walking is the best exercise, I’m going to take a few steps and scream.

This article is about how to make walking a better exercise.

True, walking is the most practicable exercise. You can pretty much do it anywhere anytime. That is no small thing.

The problem is that ordinary walking won’t push your heartbeat rate into the same zone as running or a fast bicycle ride or even a game of pickleball, one study found.

Why does intensity matter? Vigorous workouts are a more efficient way of getting fit, says cardiologist Matthew Nayor, an assistant professor at the Boston University School of Medicine, who tested the fitness of more than 3,000 participants in the Framingham Heart Study. He found that a minute of moderate to vigorous exercise had the same benefit as two or three minutes of light exercise.

How do you know if the exercise is vigorous enough? If you can carry on a conversation easily, it is probably moderate exercise, Nayor says. “If the sentences get shorter, and it is harder to carry on a conversation, you’re headed toward vigorous exercise.”

There are simple tricks you can use to transform leisurely walks into intense exercise. That includes walking up hills, carrying a weighted backpack, or working a few sprints into your daily perambulation. Perhaps the best trick of all is to walk really fast.

I have done all these things since Aug. 14, the day I turned my bicycle too sharply onto a gravel road near my New Jersey home and was slammed down, breaking two bones in my right wrist and partially tearing a tendon. That hurt.

At the time, I was training roughly 12 hours a week in preparation for an October bike ride across Italy with high school friends.

I saw a hand surgeon the next day and he told me I probably wouldn’t need surgery but that I could forget about biking in Italy. He put my wrist in a splint and said I couldn’t drive a car, much less get on a bike for a good while.

That hurt even more. Not only was I forgoing the trip to Italy, but I had spent months getting in the best shape in years. Now I was going to lose it all.

I started walking the next day to avoid that fate. Am I in biking shape? No way. But I have kept relatively fit by going on a hard daily walk. I passed a previously scheduled heart stress test a couple of weeks after my bike crash, and my resting pulse rate—one way to measure how healthy your heart is-is about the same as when I was riding 12 hours a week.

Like any exercise regime, you should talk to your doctor before doing intense walking. This is particularly true if you’re older.

Here are the tactics I used to step up my daily walking routine. Anybody with a pair of walking shoes can use these.

Sprint Once in Awhile

Short bursts of intense workout woven into your daily walk will greatly improve its cardiovascular benefits.

“High-intensity interval training is basically doing an activity ‘as hard as you can’ for about 30 seconds, whether it be walking, running, cycling, swimming, then taking one to two minutes of recovery at a more easy pace,” explains Edward Laskowski, a doctor of sports medicine at the Mayo Clinic in Rochester, Minn.

Walking in a hilly area is a natural sort of interval training. When you walk up the hill, that is the high intensity part. When you walk down, that is the recovery.

If you live in a flat area, try doing a few short sprints during your walk. Take your time to recover after each sprint. I prefer sprinting on grass, which I do at a local park.

Carry Weights

A weighted rucksack or vest can turn your stroll into a taxing workout. When I don’t feel like walking fast, I put on a 30-pound backpack and walk through a nearby forest with some hills. I’m exhausted by the time I get back to my house.

You can buy rucksacks with secured weight plates so things won’t bounce around. I’m a cheapskate, so I just took a weight set we had sitting around and used duct tape and cardboard to construct a stable weight that I could secure inside a backpack.

Pick Up Your Pace

This is the most tiring workout of all.

If you want to walk faster than 4 or perhaps 4.5 miles an hour, a brisk pace for most walkers, you have to bend your arms and swing them like a racewalker. Here’s a demonstration. The more you swing your arms like this, the faster you’ll step. Trained race walkers can walk at 9 or 10 miles an hour. You read that right. Here’s a video of Tom Bosworth of England walking a mile in 5 minutes and 31 seconds. It’s difficult to run a mile that fast.

The fastest I’ve managed recently isn’t quite 5 miles an hour—less than half the pace of Bosworth!—and a 4 mile walk at that pace left me completely thrashed. It was absolutely as hard as a run or a hard bike ride. My legs were almost quivering by the end because—I can’t believe I’m writing this—walking can be the best exercise if done right.

How Far Should You Walk to Improve Your Health? You Won’t Like the Answer.

Barron’s

How Far Should You Walk to Improve Your Health? You Won’t Like the Answer.

Neal Templin – Dec. 3, 2022

Yes, it really takes that many steps to stay in shape.Dreamstime.com

Walking 10,000 steps a day is one of those mysteriously decided good things we should all do, much like drinking eight glasses of water a day. I read it comes from a Japanese marketing campaign in the 1960s.

I’d like to report the number of steps needed for full benefit was fewer, but a fair amount of research has since been done on the subject, and it found that walking 10,000 steps a day is great for your health.

Evan Brittain, a cardiologist and associate professor at Vanderbilt University School of Medicine in Tennessee, co-wrote an October 2022 study published in Nature Medicine journal that measured how much exercise people actually got using Fitbit fitness trackers during a median of four years.

The study looked for associations between step count and disease. “We looked across every human disease that showed up in unbiased analysis,” Brittain says. “We homed in on six strongly: obesity, hypertension, diabetes, esophageal reflux, sleep apnea and depression.”

The study found the biggest protections against most diseases among those who walked close to 10,000 steps a day. For example, the research found that increasing your step count to 10,000 from 6,000 reduces the incidence of diabetes by 56%.

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Why is walking—or any form of exercise, reallyso good for us? A few reasons, says cardiologist Chad Raymond, director of cardiac rehabilitation at University Hospitals Harrington Heart and Vascular Institute in Ohio. For starters, those same endorphins that make you feel great after exercising also open up your blood vessels and help create new blood vessels.

“Regular exercise reduces blood pressure five to eight points, often what most blood pressure medicines do,” he says.

Exercise also improves the ability of skeletal muscles ability to extract oxygen from the blood, Raymond adds. And it helps improve lung function, which in turn helps the heart. 

Stop the presses: Being a couch potato isn’t good for you. So put on those comfortable shoes and go for a walk. 

Finnish leader says the brutal truth is Ukraine shows Europe isn’t ‘strong enough’ without the US

Business Insider

Finnish leader says the brutal truth is Ukraine shows Europe isn’t ‘strong enough’ without the US

John Haltiwanger – December 2, 2022

Sanna Marin meets with Volodymyr Zelenskyy
Finnish Prime Minister Sanna Marin with Ukrainian President Volodymyr Zelenskyy in Kyiv, Ukraine.Ukrainian Presidential Press Office via AP
  • Finland’s prime minister said Ukraine showed Europe was too reliant on the US for security.
  • “I must be brutally honest with you, Europe isn’t strong enough right now,” Sanna Marin said.
  • “We would be in trouble without the United States,” she added.

Finnish Prime Minister Sanna Marin said Friday the Ukraine war showed Europe was too reliant on the US for its security.

“I must be brutally honest with you, Europe isn’t strong enough right now,” Marin said in remarks at a think tank in Sydney, according to Reuters. “We would be in trouble without the United States.”

She added: “The United States has given a lot of weapons, a lot of financial aid, a lot of humanitarian aid to Ukraine, and Europe isn’t strong enough yet.

“We have to make sure that we are building those capabilities when it comes to European defense.”

The US has provided Ukraine with far more security assistance than any other country — roughly $19.1 billion since Russia launched its invasion in late February.

Russia’s unprovoked war in Ukraine marks the first major conflict in Europe since World War II, and it has prompted more urgent discussions on European security and the continent’s reliance on the US. It also pushed Finland and Sweden — two countries that have historically been neutral or militarily nonaligned — to join NATO (the process for their accession is ongoing).

In a speech last month to European diplomats, the European Union’s foreign-policy chief, Josep Borrell, questioned how the US would’ve handled the Ukraine war if former President Donald Trump were in office instead of President Joe Biden.

Trump was often critical of US security commitments in Europe and frequently chastised NATO allies over their lower levels of defense spending compared with the US. His first impeachment was also related to his dealings with Ukraine, including freezing aid to Kyiv, its capital, as he pressured Ukrainian President Volodymyr Zelenskyy to launch an investigation into Hunter Biden, the president’s son, over allegations of corruption.

Along these lines, Borrell said Europe needed to take more steps to ensure it’s not so reliant on Washington.

“What would have happened if, instead of Biden, it would have been Trump or someone like him in the White House? What would have been the answer of the United States to the war in Ukraine? What would have been our answer in a different situation?” Borrell said, adding: “These are some questions that we have to ask ourselves. And the answer for me is clear:

“We need to shoulder more responsibilities ourselves. We have to take a bigger part of our responsibility in securing security.”

Tiny Blood Clots May Be to Blame for Long COVID Symptoms, Some Researchers Say

Time

Tiny Blood Clots May Be to Blame for Long COVID Symptoms, Some Researchers Say

Jamie Ducharme – December 2, 2022

Blood samples in a laboratory
Blood samples in a laboratory

Credit – Getty Images

Blood clotting is a normal, healthy process. It’s what stops the bleeding when you slice your finger in the kitchen, for example. But sometimes, clotting goes awry. Clots that block major blood vessels can lead to potentially fatal issues like strokes or heart attacks. Tiny clots in the body’s small blood vessels can also be dangerous.

Autopsies of people who died from COVID-19 have shown that some patients develop these tiny “microclots” in their lungs, potentially contributing to respiratory failure. And now, a growing group of researchers believe microclots may also be to blame, at least in part, for Long COVID symptoms.-

People with Long COVID can experience a range of health issues—everything from neurological issues to intense fatigue and gastrointestinal distress—for months, or even years, after catching COVID-19. Researchers aren’t entirely sure why this happens. Some argue it’s because remnants of the virus linger in the body, while others think the virus triggers an abnormal immune response that essentially causes the body to attack itself.

Yet another camp of researchers believes that microclots cause Long COVID symptoms by impeding blood and oxygen flow to the body’s organs and tissues. That hypothesis is alluring because it suggests an intuitive treatment approach: if you can flush clots from the blood, you should be able to get rid of symptoms.

Resia Pretorius, head of the physiological sciences department at South Africa’s Stellenbosch University, is one of the leaders of that camp. In August 2021, she co-authored the first paper to raise the microclot theory. Still, Pretorius isn’t ruling out other explanations—or a combination of them. In fact, she believes the leading hypotheses about Long COVID’s causes are interconnected. She posits that lingering viral remnants may damage the cells that line the blood vessels, prompting the formation of inflammation and microclots, which could in turn make the immune system attack itself. “It’s connected,” she says. “It can be seen as interacting with each other, not one [theory] above the other.”

David Putrino, a Long COVID researcher at New York’s Mount Sinai health system who has collaborated with Pretorius, agrees that microclots are likely a piece of the larger Long COVID puzzle. “Microclots are kind of like exhaust fumes,” he says. “They’re showing up because something systemically is going wrong.” Putrino’s research with Yale University’s Akiko Iwasaki (who has also collaborated with Pretorius) suggests Long COVID patients have high levels of systemic inflammation, which he says could lead to the formation of microclots.

“If we can modulate any part of that cascade with therapeutics,” Putrino says, “people are [hopefully] going to start to feel better.”

There is no proven cure for Long COVID. But in December 2021, Pretorius’ research group posted online a study (which has not yet been peer reviewed) showing that 24 Long COVID patients experienced improvements in symptoms, including fatigue, after being treated with blood-thinning drugs.

But some experts have doubts about that approach. Dr. Adam Cuker, clinical director of Penn Medicine’s Blood Disorders Center and a member of the American Society of Hematology, says so much remains unknown about microclots that it feels premature to begin treating people with drugs that come with significant risks, such as excessive bleeding.

“The scientific part of me would say, ‘It would be better if we had more evidence from basic science labs before we turn this into a clinical trial,’” Cuker says. “The tension is that I recognize that there are patients suffering out there and desperate for answers.”

At the moment, Cuker says some of the studies on microclots are “hypothesis-generating,” but he has doubts about some of the ways that researchers are looking for microclots in the blood. For example, the protocol developed by Pretorius’ team involves drawing blood and adding a fluorescent agent. Researchers then compare the sample’s appearance under a microscope with fluorescent-treated samples from healthy control patients. “That’s a very artificial system,” Cuker says. “It’s very different from an autopsy, where you can see with your own eyes that there were clots in the body.”

To help standardize the research process, Putrino’s team is developing an objective way to detect the presence of microclots using a computer vision algorithm. From there, he says, the next step is to determine whether the amount of microclots in a person’s body correlates with their symptom severity. His lab has already gathered some unpublished data that suggest extensive clotting is linked to increased cognitive impairment—another finding, albeit a premature one, that suggests microclots are at least partially responsible for Long COVID symptoms.

Putrino acknowledges that there’s a long way to go when it comes to microclot research, and research on Long COVID in general. But he says it’s necessary to think outside the box, “especially when people’s lives are at stake.”

Neurologists say accelerated brain aging in Black people can be countered by lifestyle changes

NBC News

Neurologists say accelerated brain aging in Black people can be countered by lifestyle changes

Curtis Bunn – December 2, 2022

Black physicians are fascinated but not surprised by recent data that suggests Black people’s brains are likely to age faster than those of other races due to stressors such as racism. However, doctors said lifestyle changes and preventative care could help slow some of the decline.

In a study published last month in the journal JAMA Neurology, researchers from Columbia University found racial and ethnic disparities in brain markers of Alzheimer’s disease and related cases of dementia. The scientists analyzed MRI scans of nearly 1,500 participants, and found that Black adults in their mid-50s were more likely than white or Hispanic adults of the same age group to show white-matter lesions in their brains, which are indicators of cerebrovascular disease or cognitive decline.

The authors noted that “social forces” may have played a part in the accelerated brain aging seen among their Black subjects. In particular, the study says the weathering hypothesis — which states that “chronic exposure to social and economic disadvantage leads to accelerated decline in physical health outcomes”— could cause Black middle-aged adults on average to have cerebrovascular disease earlier in life.

JAMA Neurology did not immediately respond to request for interview.

Dr. Philippe Douyon. (Courtesy of Dr. Bouyon)
Dr. Philippe Douyon. (Courtesy of Dr. Bouyon)

Dr. Philippe Douyon, a neurologist in New Jersey at the Inle Brain Fit Institute who hosts The Brain Prophets Podcast, said he’s concerned that some may interpret the study to mean that Black people are naturally predisposed to Alzheimer’s. “That’s not the case at all. A lot of things contribute to dementia and Alzheimer’s, like high blood pressure and diabetes. Also, chronic stress kills neurons or brain cells in the part of the brain responsible for making new memories,” Douyon said.

He also noted that chronic stress as a result “of racism or health inequalities due to racism” can raise someone’s risk of developing cognitive disease. “But I would not want people to think that it has anything to do with the fact that the color of their skin is black,” he said.

Dr. Richard D. King, a neurologist and associate professor at the University of Kentucky College of Medicine, said many people who experience a deterioration in brain function do not realize there’s a problem until there’s been “quite a bit of decline.”

He added that stress can exacerbate hypertension, which can make a person more prone to cognitive decline.

Dr. Richard D. King. (Pete Comparoni)
Dr. Richard D. King. (Pete Comparoni)

“Elevated blood pressure is a very strong risk factor for worsening cerebrovascular disease,” King said. “But two people might respond to the exact same stress in very different ways. It’s a difficult thing to measure on an individual basis.”

Donald Grant, a psychologist and the executive director of Mindful Training Solutions, a firm that designs diversity, equity and inclusion programs for businesses, said the stress of being Black in America can wear on the brain.

“We’re talking about Black folks experiencing these higher degrees of racialized stress, meaning we’re watching ourselves being murdered through racism, we’re watching ourselves not get jobs because of racism,” Grant said. “We’re watching ourselves not get housing and equal opportunities through racism. That creates a unique stress that nobody else experiences and our brains are being impacted by it.”

Minimizing the risk 

Douyon said there are many ways to slow brain aging, including maintaining a healthy diet and getting proper rest.

“You can minimize your risk of dementia by eating healthy — more fruits and grains and vegetables and less animal fats and sweets in moderation,” he said. “You need to make sure you’re getting six to eight hours of sleep every night.”

Douyon said sleep deprivation in someone’s mid-life years — 20s through 50s — can raise the risk of  dementia in their 60s, 70s or 80s. He said it’s important to not only get sleep, but deep sleep, known as non-rapid eye movement (NREM) sleep.

“That’s when the brain essentially clears out the toxins that are developing throughout the day. And when these toxins build up, they develop into plaques and those are the kind of plaques that we see in people with Alzheimer’s,” he said.

King added that it’s also important to keep the mind and body active.

“Exercise is a big one,” he said, “and that’s something that we’re actually pretty good at least until we get older, when we get kind of lazy. But physical activity is my best anti-aging formula.” He recommends spending 30 minutes per day doing “something that’s kind of vigorous and gets your heart rate up — gets you a little sweaty.”

King and Douyon also suggested playing board games, solving puzzles and reading as ways to exercise the brain.

“Learning a new hobby makes a big difference,” King said. “And then staying socially active. Keeping those connections with family with friends, with church and social organizations provide meaningful interaction. If you get isolated, you just don’t do as well as those that maintain those connections.”

In addition, Grant thinks it’s equally important to find ways to manage stress.

One option is through activities like restorative yoga, which Grant said can help address stress and regulate blood pressure and brain function.

Dr. Donald Grant. (Courtesy of Dr. Grant.)
Dr. Donald Grant. (Courtesy of Dr. Grant.)

“Racism creates a unique stress that nobody else experiences,” he said. “We have to begin building stress relief techniques in school that specifically speak to race-based stress and trauma. This type of yoga is one of them.”

King noted that “the study certainly suggests that if we were able to do things like close the socioeconomic gaps and provide more opportunities and reduce the number of microaggressions Black people face, you might see some change in that.”

He added that high blood pressure and diabetes, which are prevalent in Black communities, can be managed with proper health care and while both are very common, they are “very treatable.”

“What gets measured, gets managed,” King said. “And so you have to measure it. You have to go to your primary care doctor and check your blood pressure and blood sugar level. And you have to take your medications on a regular basis.”

Douyon said a holistic approach is likely the best way to slow down brain aging.

“You want to constantly be learning, constantly evolving, learning new skills, interacting with different people, learning new languages, traveling the world, having new experiences,” he said. “Being creatures of habit is killing our neurological potential. So, you don’t want to be sedentary — that causes the brain to atrophy and to shrink. These are things that we can do every day to minimize the risk of us developing something like Alzheimer’s.”

One Type of Exercise May Reduce Risk of Metastatic Cancer by 72%, Research Finds

Bicycling

One Type of Exercise May Reduce Risk of Metastatic Cancer by 72%, Research Finds

Madeleine Haase – December 2, 2022

exercise and cancer
Exercise May Reduce the Risk of Metastatic CancerJustin Paget – Getty Images

We all know that exercise is good for you, but new research shows just how beneficial regular exercise can be for our health.

A study from Tel Aviv University, published in Cancer Researchis the first to investigate the impact of exercise on the internal organs in which metastases (secondary cancerous growths) usually develop, like the lungs, liver, and lymph nodes. And what the researchers found was truly remarkable: aerobic exercise may reduce the risk of metastatic cancer by 72%.

In a press release, lead researchers Carmit Levy, Ph.D., and Ytach Gepner, Ph.D., said that these findings added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. “If the general message to the public so far has been ‘be active, be healthy,’” they say, “now we can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.”

The study included both mice and humans—mice trained under a strict exercise regimen, and healthy human volunteers were examined before and after running.

Human data was also obtained from an epidemiological study that monitored 3,000 individuals for about 20 years—during that time, 243 new cancer cases were recorded. Researchers found that there was 72% less metastatic cancer in participants who reported regularly exercising at a high intensity, compared to those who did not engage in physical exercise.

The mice exhibited a similar outcome, which enabled the researchers to use the animal model to better understand what might be leading to the reduction in cancer. They found that aerobic activity significantly reduced the development of metastatic tumors in the lymph nodes, lungs, and liver of the mice. The researchers hypothesized that in both humans and model animals, this outcome is related to the body’s ramped-up use of glucose for fuel induced by exercise.

“Examining the cells of these organs, we found a rise in the number of glucose receptors during high-intensity aerobic activity—increasing glucose intake and turning the organs into effective energy-consumption machines, very much like the muscles,” Levy says in the press release.

According to the researchers, this happens because the organs must compete for sugar resources with the muscles, which are known to burn large quantities of glucose during physical exercise. As a result, there is less glucose—therefore energy—available for the cancer to metastasize, or grow and spread.

On top of these encouraging findings, Levy explains that “when a person exercises regularly, this condition becomes permanent: the tissues of internal organs change and become similar to muscle tissue.” We all know that sports and physical exercise are good for our health. However, this study in particular examines the internal organs, and discovered that exercise changes the whole body, so that the cancer cannot spread, and the primary tumor also shrinks in size, says Levy.

What is metastatic cancer?

Metastatic cancer is a cancer that spreads to another place which is not the primary location of the cancer, says Carolina Gutierrez, M.D., cancer rehabilitation specialist with McGovern Medical School at UTHealth Houston and an attending physician at TIRR Memorial Hermann.

How does exercise affect your internal organs where metastases typically develop?

We knew from previous observational studies that exercise has a very important positive impact that can range from decreased risk of recurrence to decreased risk of getting certain cancers, but we didn’t really understand how that works, says Marlene Meyers, M.D., medical oncologist at NYU Langone Perlmutter Cancer Center.

Meyers explains that this study actually sought to look at what happens in mice. “Essentially, what it showed was that mice who exercised at high intensity had an increase in glucose receptors or sugar receptors in these organs.” She notes that the feeling from the researchers is that this increase in receptors competes with the glucose (sugar) that might go to cancer cells, which gives them the energy to spread.

How does exercise reduce your risk for cancer?

There are many reasons why exercise can reduce your risk for cancer, says Gutierrez. “Exercise helps maintain a healthy weight and body composition, reduces fat, helps with glucose levels, and helps control high blood pressure. It also helps reduce the risk of diabetes, insulin resistance and in turn reduces a person’s overall cancer risk.”

However, when it comes to how high-intensity exercise, in particular, affects your cancer risk, the science is less clear. “We do know that any exercise can decrease the risk of recurrence in some cancers, so it’s not clear specifically whether high intensity makes as big a difference versus regular exercise, or how long you have to sustain high-intensity exercise or how often,” says Meyers.

In this study, the researchers defined high-intensity exercise as exercise where your heart rate is 80% to 85% of maximum pulse rate, says Meyers. Due to these findings, she says that “high-intensity exercise may be the type of exercise that actually can increase glucose receptors.” In the end, Meyers says that these findings do support what we know about exercise, “but doesn’t clearly say what we should be recommending for humans.”

The bottom line on exercise and cancer

Exercise is good for you, says Gutierrez. “It will help you with your overall health and reduce the risk not only of cancer but of metastases.”

However, Meyers warns that we need to take these promising findings with a grain of salt. “When we see these retrospective studies, we’re relying on what people report…There are many other factors that go into reduced risk, whether it’s exercise alone, exercise and nutrition, where you live, your family history,” she explains.

Future studies need to be more randomized, especially in our survivor populations, says Meyers.

Also, a reminder that exercise is not a substitute for medical care or cancer screenings, and it’s not an end all be all, says Meyers. “Even professional athletes get cancer,” so although exercise can do a whole lot of good for you, there’s no cure for cancer yet.

Suffering from flu, RSV or COVID-19? How you can tell the difference

Good Morning America

Suffering from flu, RSV or COVID-19? How you can tell the difference

Mary Kekatos – December 2, 2022

Suffering from flu, RSV or COVID-19? How you can tell the difference

The U.S. is facing a surge of respiratory viruses, mainly driven by COVID-19, influenza and respiratory syncytial virus, or RSV.

Flu and RSV have appeared earlier than usual and have particularly affected children, leading to 78% of pediatric hospital beds being full, according to the U.S. Department of Health & Human Services.

All three viruses have symptoms that are similar, which can make them difficult to tell apart. But knowing which virus a person has can help them receive proper treatment or, if need be, let them know if they need to isolate.

MORE: Two-thirds of states reporting ‘very high’ or ‘high’ levels of flu-like activity: CDC

Here are some questions to consider when trying to determine if you have COVID-19, flu or RSV.

What are the symptoms?

COVID-19, flu and RSV are more similar to each other than they are different in terms of symptoms.

One of the only symptoms exclusive to one virus and not the others is loss of taste and smell, which has been a hallmark symptom of COVID-19.

PHOTO: Symptoms of COVID-19, RSV, and Flu (ABC News Photo Illustration, CDC, Mayo Clinic)
PHOTO: Symptoms of COVID-19, RSV, and Flu (ABC News Photo Illustration, CDC, Mayo Clinic)

However, public health experts told ABC News the absence of one of the symptoms does not mean a patient doesn’t have a particular virus and that the only way to be sure is to get tested.

“In most cases, if anybody has generic symptoms, such as fever, cough, runny nose, there’s going to be no real way to distinguish which one is which without a test,” Dr. Scott Roberts, an assistant professor and the associate medical director of infection prevention at Yale School of Medicine, told ABC News.

How quickly did symptoms come about?

Flu symptoms typically appear rather quickly while symptoms of RSV and COVID-19 appear more gradually, according to the Centers for Disease Control and Prevention.

COVID-19 has an incubation period of two to 14 days while RSV has an average incubation of about five days but can be anywhere from two to eight days.

MORE: RSV cases hit 2-year high, CDC data shows

By comparison, flu has an incubation period of one to four days.

“So, if somebody says, ‘I went to Thanksgiving party yesterday where someone had flu and the next day I had a fever,’ I can already tell you that’s flu,” Roberts said. “I know it’s much too fast for it to be COVID.”

How old is the patient?

Public health experts told ABC News that depending on how old a patient is can affect the severity of the disease.

For example, RSV is most severe for infants younger than six months older and young children, particularly those with weakened immune systems or congenital lung or heart disease.

PHOTO: FILE PHOTO: People enter a pharmacy next to a sign promoting flu shots in New York Jan. 10, 2013. (Andrew Kelly/Reuters, FILE)
PHOTO: FILE PHOTO: People enter a pharmacy next to a sign promoting flu shots in New York Jan. 10, 2013. (Andrew Kelly/Reuters, FILE)

“Children under six months of age and children maybe a little bit older who have underlying medical conditions or who were premature, end up with the shortness of breath and the difficulty breathing because their airways are just so small, and they don’t have a lot of reserve there to move air through the small air passages when they’re inflamed,” Dr. Shira Doron, an infectious disease physician and hospital epidemiologist at Tufts Medical Center in Boston, told ABC News.

However, relatively young and healthy adults are not likely to have a severe case of RSV if they get infected.

“In children, we tend to see a lot more of the sort of bronchiolitis respiratory issues with RSV,” Dr. Allison Bartlett, an associate professor of pediatrics at the University of Chicago Medical Center, told ABC News. “Adults, when they get RSV, it tends to be a like a cold. It’s just like one of the colds that you would get every year.”

With COVID-19, age is the number one risk factor when it comes to severe disease and death.

MORE: RSV hospitalizations in seniors much higher than any point in prior seasons

As of the week ending Nov. 19, Americans aged 65 and older make up 92% of all deaths from the virus, according to an ABC News analysis of data from the Centers for Disease Control and Prevention.

What treatments or precautions do I need to follow?

“Not everyone needs to be tested; our pediatricians’ offices and hospitals are overloaded,” Bartlett said. However, figuring what the illness is can help treat the patient and potentially family members or close contacts, she said.

For example, with COVID-19, it’s important to follow CDC guidelines, which include isolating for at least five days — or longer if symptoms don’t improve — and wearing a mask around others.

Additionally, they can be prescribed Paxlovid if they are at risk of severe illness.

With flu, patients can receive Tamiflu to shorten the course of their illness as long as it is given early on and people who are exposed to flu can receive the treatment to prevent them from getting sick.

However, the most important thing a person can do if they are infected — when possible — is to stay home.

“If you’re really, really sick, go the hospital. If you’re not that sick, and it looks like a common cold, then you stay home and don’t infect people,” Doron said.