The Tarbabys Blog

Independent

Vitamin D could prevent Alzheimer’s, new research reveals

Mark Waghorn – December 7, 2022

Vitamin D pills could stave off Alzheimer’s disease, according to new research.

Brains of older people with higher levels of the nutrient function better, say nutritionists.

The main natural source is sunlight but wrinkly skin is less efficient at converting it, meaning older individuals are more likely to be deficient.

Corresponding author Dr Sarah Booth said: “This research reinforces the importance of studying how food and nutrients create resilience to protect the ageing brain against diseases such as Alzheimer’s and other related dementias.”

The number of cases worldwide will triple to more than 150 million by 2050. And with no cure in sight, there is an increasing focus on preventive measures such as lifestyle.

Dr Booth and colleagues examined post mortem samples of brain tissue from 209 participants in the Rush Memory and Ageing Project that began in 1997.

It is the first analysis of its kind, comparing vitamin D levels in adults who suffered from varying rates of cognitive decline.

Lead author Professor Kyla Shea said: “Many studies have implicated dietary or nutritional factors in cognitive performance or function in older adults, including many studies of vitamin D, but all of them are based on either dietary intakes or blood measures of vitamin D.

“We wanted to know if vitamin D is even present in the brain, and if it is, how those concentrations are linked to cognitive decline.”

The team at Tufts University in Massachusetts found more vitamin D in all four regions looked at correlated with better mental skills.

Two areas are associated with changes linked to Alzheimer’s, one with dementias due to to blood flow and the other without any associations with brain or vascular diseases.

Participants’ cognitive function was assessed at the outset and as they aged – with irregularities in their brain tissue identified after death.

No connection was found between vitamin D levels and any of the physiological markers associated with Alzheimer’s disease.

These included rogue amyloid beta proteins that gather in plaques, Lewy body disease or chronic or microscopic strokes.

This means it is still unclear exactly how vitamin D might affect brain function.

Prof Shea said: “Dementia is multifactorial, and lots of the pathological mechanisms underlying it have not been well characterised.

“Vitamin D could be related to outcomes that we didn’t look at yet, but plan to study in the future.”

Vitamin D is also known to vary between racial and ethnic populations, and most of the participants in the original cohort were white

The researchers are planning followup studies using a more diverse group of subjects to look at other brain changes associated with cognitive decline.

They hope their work leads to a better understanding of the role vitamin D may play in staving off dementia.

Experts caution people not to use large doses of vitamin D supplements as a preventive measure.

The recommended dose of vitamin D is 600 IU (international units) for under 70s and 800 for those older.

Excessive amounts can cause harm, and have been linked to the risk of falling.

Prof Shea said: “We now know that vitamin D is present in reasonable amounts in human brains, and it seems to be correlated with less decline in cognitive function.

“But we need to do more research to identify the neuropathology that vitamin D is linked to in the brain before we start designing future interventions.”

The study was published in the journal Alzheimer’s & Dementia.

Fortune

Nearly half of COVID patients worldwide still have symptoms after 4 months, according to a giant new study

Erin Prater – December 7, 2022

Almost half of COVID survivors globally—both children and adults—have lingering symptoms four months later, according to a landmark new study.

Researchers at the University of Leicester in England performed an analysis of nearly 200 studies of prior COVID patients, involving nearly 750,000 people in all. The patients—some of whom were hospitalized and some of whom weren’t—lived across the globe.

More than 45% of study participants had at least one lingering symptom four months out from their initial infection. A quarter of the patients reported fatigue, and a similar number said they felt pain or discomfort. Meanwhile, sleep issues, breathlessness, and problems participating in normal daily activities were reported in just under a quarter of patients, according to the study.

Often, no clinical abnormalities could be found to explain such symptoms. But some signs were reported in many patients who had been hospitalized with COVID, including changes in lung structure and function. An abnormal CT scan and/or X-rays were found in nearly half of previously hospitalized patients, in addition to a decreased capacity to diffuse carbon monoxide in nearly a third of patients.

“Changes in pulmonary function are similar to those observed following other viral infections including SARS and MERS,” the authors wrote.

When nonhospitalized COVID survivors were singled out, more than a third of them had lingering symptoms at four months, the study found.

“The reasons as to why so many patients are experiencing long COVID remains unknown,” the authors wrote, adding that possible causes include organ damage, inflammation, altered immune systems, and psychological effects.

While some studies have found a higher rate of long COVID in females, the study out of Leicester didn’t find that any particular age group or gender experienced higher rates of the disabling condition. Researchers weren’t able to reliably assess any potential association with race, as only a quarter of studies examined provided participants’ race or ethnicity.

Nearly 20% of American adults who’ve had COVID—an estimated 50 million—report having long COVID symptoms, according to data collected by the U.S. Census Bureau this summer.

Long COVID is roughly defined as symptoms that persist or appear long after the initial infection is gone, but a consensus definition has not yet been broadly accepted. Many experts contend that long COVID is best defined as a chronic-fatigue-syndrome–like condition that develops after COVID illness, similar to other post-viral syndromes that can occur after infection with herpes, Lyme disease, and even Ebola. Other post-COVID complications, like organ damage and post–intensive-care syndrome, should not be defined as long COVID, they say.

Today

Forget diets: This is how to lose weight and keep it off for good

Kristin Kirkpatrick – December 6, 2022

Losing weight is notoriously difficult. And as hard as it is to get the scale to tick down, it’s even harder to keep the weight off. Unfortunately, recent studies show that most of us will put weight back on in two years. By five years, almost all of it may come back. Further, many people end up gaining more weight than they lost.

But keeping your focus on the end goal — better health and longevity — may increase your odds more than any extreme diet and fitness regime. In fact, the path to maintaining a healthy weight starts long before you get close to your goal weight. Here are some evidence-based ways to approach weight loss and maintenance in a healthy way.

Don’t fixate on the number on the scale

When I see patients for the first time, we discuss their health goals. The truth is that most people are aiming for a particular number. “I want to lose this many pounds,” or “I want to reach this number on the scale.” But fixating on a goal weight may work against a lot of us. Studies show that focusing on the numbers that speak to overall health may be more impactful in sustained behavior change. So, throw out the scale and focus on your lipid panel, your blood-sugar numbers, or perhaps even your inflammation markers.

Paying attention to health, rather than weight can shift the reason why you want to drop pounds in the first place. Other quality of life parameters — like better sleep, less chronic pain or increased energy —can all be major motivation for changing your habits. Finally, if you must rely on a scale, choose an option that assess body fat and muscle mass.

Learn from weight maintenance warriors 

Multiple studies have tried to demystify why one person succeeds at weight loss while another doesn’t. Two studies in the journal Obesity surveyed almost 6,000 individuals who had participated in a structured weight-loss program. The surveyed participants lost on average 50 pounds and kept their weight off for three years or more.

Based these studies, as well as previous data, people who were successful at losing weight and keeping it off did these things:

• Made healthy food choices most of the time — and found that these choices effortless and “unconscious.”
• Self-monitored and journaled about their food intake.
• Consumed lower calorie, yet higher nutrient dense foods.
• Engaged higher levels of physical activity.
• Made continued goal setting a priority.
• Celebrated their past achievements and embraced their current health.

Another crucial component of weight loss success was mindset — especially in the face of challenges and adversity. While both health and appearance were significant motivating factors, greater confidence and being more mentally and physically fit topped the list for being able to maintain healthy habits.

Move more

Exercise, as it turns out, is not the secret weapon to successful weight loss. When it comes to weight loss, your diet has been found to play a much more significant role in terms of pounds lost. However, when it comes to keeping those pounds from coming back, you need to move more.

A recent study from the University of Colorado found that when individuals engaged in physical activity, they maintained more steps per day (about 12,000) and maintained a higher energy expenditure. Another study published in the Archives of Internal Medicine found that in order to maintain weight loss, women needed to exercise at least 55 minutes, five days per week. This recommendation surpasses the current guidelines for exercise, which calls for only 150 minutes of moderate physical activity throughout the week and two days of muscle-building training.

Fall in love with protein

A 2020 study in the Journal of Nutrition found that high-protein diets were associated with greater success in maintaining weight loss. The study showed that having more protein often counteracted the process of adaptive thermogenesis — a state where the body adapts to a new weight by altering energy expenditure. An easy way to up your protein intake is to add some kind of protein to every meal and snack. For example, consuming eggs whites at breakfast, hummus for a snack and wild salmon for dinner.

Assess your social circle

If you’ve ever had a friend tell you that “one bite of something won’t kill you,” you know that your loved ones can have a major influence on your health habits. A study from The University of North Carolina found that individuals that lose weight may face a “lean stigma” where friends and family consciously or unconsciously sabotage or undermine efforts of the successful weight loss.

Researchers found that effective communication techniques were one way to mitigate comments and discouraging attitudes from friends and family. For example, telling loved ones ahead of time your motivation to lose weight or communicating weight-loss efforts as a way to obtain better health — and not better appearance — is a good way to let your loved ones know why your health goals are important to you.

Accept the fact that there’s no magic weight loss fix

“Unfortunately, there’s no magic bullet to lose weight quickly and sustainably,” Samantha Cassetty, a registered dietitian and author of “Sugar Shock,” told TODAY.com. “Some people like the idea of a jump-start plan, which may involve fewer calories or carbs as you’re starting out. If that helps you feel motivated and get in the right mindset to form lasting habits, go for it. But for permanent weight loss, be realistic about what you can sustain,” Cassetty explained.

Also, Cassetty added, it’s important to keep in mind that when you fast weight loss, you might overlook behaviors that need to be addressed — such as nighttime snacking or eating when you’re bored. Cassetty said that a jump-start plan probably doesn’t include your favorite foods, but it’s much more realistic to learn how to live with indulgences than to try to avoid them forever. “Overly restricting less healthy foods can be stressful, which can stall weight loss efforts,” said Cassetty.

Embrace your body — and adapt to it when it changes

Studies indicate that frequent attempts to lose and then regain weight (often referred to as yo-yo dieting) can have an adverse impact on health and lead to an increased risk of further weight gain. A 2016 study showed that repeated dieting could cause the brain to think it’s going through periods of famine. In response, the body continues to work toward fat storage to prepare for the next round. The body adapts and becomes efficient at the current lower weight, and if you don’t adapt with it, you will most likely gain the weight back.

Imagine putting on a 20-pound vest and taking a walk around the block. The walk would be challenging, and you may have to work harder during the activity. Exertion is higher, and with it so are the calories you are burning as well. Now imagine taking the vest off. The body does not have to work that hard anymore to get you around the block. If you’ve lost 50 pounds, and changed nothing in your physical activity or eating habits, you are more likely to gain that weight back. Your metabolism works with the new weight, so constant adaptation is essential.

Let go of the idea that you can target belly fat

There’s a lot of trending advice about how to lose belly fat, but the truth is that it’s difficult to target weight loss. “If you lose weight, you will lose fat in your midsection, but it’s impossible to target belly fat,”Cassetty told TODAY. However, belly fat tends to respond well to modifications in your diet and activity, Cassetty explained. “And there’s evidence that when your waist shrinks, cholesterol and blood sugar levels improve,” she said.

If you experience, belly-specific health issues, you may need to address those. “If your belly seems bigger after you eat and you experience painful bloating, it could be a sign of a food sensitivity or gut health problem,” Cassettty said. “If this is the case, consult with your healthcare provider to determine the cause and treatment plan.”

Take a break from dieting

If your idea of weight loss and weight maintenance is a “diet,” then studies show you are likely bound for failure. A 2017 randomized controlled trial found that individuals that took breaks from dieting were more likely to lose weight and keep it off. The cornerstone of dieting is often restriction. The more restricted, the less we lose. So, take a break from diets and embrace lifestyle changes instead.

Weight loss — especially when the reduction occurs in the midsection — can have a significant impact on health and longevity, though. When you focus on longevity, happiness and increased energy, your reasons for losing the weight in the first place will be clear and your ability to maintain better health will be easier.